Anne De Paepe Selected Research

Neuroblastoma

3/2014	Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer.
6/2011	Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3.
9/2010	Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification.
11/2009	RNA pre-amplification enables large-scale RT-qPCR gene-expression studies on limiting sample amounts.
11/2009	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.
6/2008	CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23.
10/2006	Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma.
1/2006	Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.
8/2004	No evidence for involvement of SDHD in neuroblastoma pathogenesis.
2/2004	Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons.

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Anne De Paepe Research Topics

Disease

13	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 01/2018 - 04/2004
11	Neuroblastoma 03/2014 - 07/2003
9	Neoplasms (Cancer) 03/2014 - 06/2002
7	Osteogenesis Imperfecta (Lobstein Disease) 01/2018 - 03/2007
6	Marfan Syndrome (Marfan's Syndrome) 12/2017 - 04/2002
5	Joint Instability (Joint Laxity) 01/2019 - 10/2012
4	Cutis Laxa 01/2017 - 09/2002
4	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 04/2015 - 03/2007
3	Fatigue 01/2016 - 10/2010
3	Autosomal Recessive Type VII Ehlers-Danlos Syndrome 01/2016 - 11/2004
3	Loeys-Dietz Syndrome 01/2014 - 04/2006
3	Hemorrhage 08/2011 - 12/2004
2	Cicatrix (Scar) 01/2019 - 10/2012
2	Pain (Aches) 01/2016 - 12/2014
2	Ovarian Neoplasms (Ovarian Cancer) 04/2015 - 07/2003
2	type 1 Stickler syndrome 11/2014 - 08/2010
2	Chromosome Aberrations (Chromosome Abnormalities) 03/2014 - 01/2002
2	Aneurysm (Aneurysms) 01/2014 - 01/2012
2	Thoracic Aortic Aneurysm 07/2013 - 05/2013
2	Contracture 03/2011 - 11/2010
2	Type IV Ehlers-Danlos Syndrome 01/2011 - 10/2010
2	Rupture 10/2010 - 04/2007
2	Fabry Disease (Fabry's Disease) 12/2008 - 01/2008
2	Blepharophimosis, Ptosis, and Epicanthus Inversus 11/2008 - 02/2003
1	Ebola Hemorrhagic Fever 01/2021
1	Choroidal Neovascularization 01/2020
1	Osteoporosis 01/2019
1	Ventricular Dysfunction 12/2017
1	Musculoskeletal Abnormalities 11/2016
1	Peri-Implantitis 04/2016
1	Atrophy 04/2015
1	Autonomic Nervous System Diseases (Dysautonomia) 12/2014
1	Vascular Calcification 04/2014
1	Menkes Kinky Hair Syndrome (Menkes Disease) 04/2014
1	Rhabdomyosarcoma 03/2014
1	Medulloblastoma 03/2014
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2014
1	Retinoblastoma (Glioblastoma, Retinal) 03/2014
1	Osteosarcoma (Osteogenic Sarcoma) 03/2014
1	Ewing Sarcoma (Sarcoma, Ewing) 03/2014
1	Cystinosis 09/2013
1	Craniosynostoses (Craniosynostosis) 09/2013
1	Fanconi Syndrome (Syndrome, Fanconi) 09/2013

Drug/Important Bio-Agent (IBA)

8	Collagen Type I (Type I Collagen)IBA 01/2018 - 03/2007
8	CollagenIBA 01/2017 - 04/2004
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 09/2002
4	EnzymesIBA 01/2016 - 11/2004
4	Procollagen Type IIBA 08/2015 - 11/2004
4	Messenger RNA (mRNA)IBA 04/2014 - 08/2006
4	Fibrillin-1IBA 07/2013 - 04/2002
3	Transforming Growth Factor-beta Type I ReceptorIBA 05/2013 - 10/2011
3	Collagen Type V (Type V Collagen)IBA 10/2012 - 03/2008
3	Vitamin K FDA Link 08/2011 - 03/2007
3	nutlin 3IBA 06/2011 - 10/2006
3	DNA (Deoxyribonucleic Acid)IBA 08/2010 - 02/2004
3	FibrillinsIBA 01/2006 - 09/2003
2	alpha2 Subunit Collagen Type IIBA 04/2017 - 04/2007
2	ProcollagenIBA 01/2016 - 11/2004
2	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 01/2016 - 12/2014
2	Transforming Growth Factor beta (TGF-beta)IBA 04/2014 - 04/2006
2	CopperIBA 04/2014 - 09/2013
2	RNA (Ribonucleic Acid)IBA 04/2014 - 11/2009
2	Amino Acids FDA Link 09/2013 - 04/2003
2	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 07/2013 - 05/2013
2	Peptide Hydrolases (Proteases)FDA Link 05/2013 - 11/2004
2	ElastinIBA 11/2011 - 12/2006
2	CalciumIBA 06/2011 - 09/2002
2	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)IBA 03/2011 - 05/2005
2	alpha-Galactosidase (Beano)IBA 12/2008 - 01/2008
2	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 11/2008 - 02/2003
2	Retinaldehyde (Retinal)IBA 09/2007 - 03/2005
2	IntegrinsIBA 03/2007 - 04/2004
2	Complementary DNA (cDNA)IBA 02/2004 - 07/2003
1	VaccinesIBA 01/2021
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Losartan (Cozaar)FDA LinkGeneric 12/2017
1	Adenosine Triphosphatases (ATPase)IBA 01/2017
1	Interleukin-1 (Interleukin 1)IBA 04/2016
1	Hypnotics and Sedatives (Sedatives)IBA 01/2016
1	Dermatan SulfateIBA 05/2015
1	GonadotropinsIBA 04/2015
1	NucleotidesIBA 04/2015
1	Adenosine Triphosphate (ATP)IBA 04/2015
1	glutamyl carboxylase (gamma-glutamyl carboxylase)IBA 04/2015
1	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 04/2015
1	propylene diquat (PDQ(+))IBA 12/2014
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 04/2014
1	Therapeutic UsesIBA 03/2014
1	Pharmaceutical PreparationsIBA 03/2014
1	Biological ProductsIBA 03/2014
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2014
1	Cysteamine (Mercaptamine)FDA Link 09/2013
1	Copper Transport ProteinsIBA 09/2013
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 09/2013
1	Glycoproteins (Glycoprotein)IBA 08/2013

Therapy/Procedure

6	Therapeutics 12/2017 - 01/2002
1	Renal Dialysis (Hemodialysis) 09/2013
1	Sutures (Suture) 09/2013
1	Kidney Transplantation 09/2013